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Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Monday, April 11, 2011

Test Your Telomere Length... Now!

11 April 2011

I've been following the scientific study of telomere length since reading Matt Ridley's classic popular science work: "Genome."

To cite a recent online article in Scientific American:

"Telomeres are caps on the ends of chromosomes, protecting them much as plastic tips on the ends of shoelaces keep the laces from fraying. Whenever chromosomes—the store­houses of our genes—are replicated in preparation for cell division, their telomeres shorten. That shrinking has led many scientists to view telomere length as a marker of biological aging, a “molecular” clock ticking off the cell’s life span, as well as an indicator of overall health.

"Studies comparing the telomere length of white blood cells among groups of volunteers show distinct correlations between telomere length and lifestyle. Those who exercise regularly have longer telomeres than those who do not. Folks who perceive themselves as the most stressed have shorter telomeres than those who see themselves as the least. Certain diseases, too, correlate with shorter telomeres, including cardiovascular (illness), obesity and Alzheimer’s."

Well, the long and the short of it - in this case, in fact the critical factor - is that it is now possible to get your telomere length tested.

Scientific American is not a "commercial" publication, so they did not provide the link to the company that plans to offer this service, but here they are: "Life Length."

Contacts for the company are as follows:

Stephen Matlin
smatlin@lifelength.com

Nuño Arroyo
narroyo@lifelength.com

Marisol Quintero
mquintero@lifelength.com

I have already e-mailed Mr. Matlin, and he indicates that the test is presently available at a cost of €500.

His contact information is as follows:

Stephen J.Matlin

Chief Executive Officer




Agustín de Betancourt, 21 – 8th floor

Madrid, Spain 28003

T +(34) 91 395 6368

M +(34) 629 343 694

www.lifelength.com

I'll let you know exactly what's up as I find out more.

Again, telomere length is one of the critical factors in aging.

Though we're a long way from being able to modify telomere length in individual humans, another company (Geron Corp.) is working on doing exactly this. Their present focus is on the use of telomerase blocking to control the proliferation of cancer cells.

From Geron's website:

"We and others have shown that when the enzyme telomerase is introduced into normal cells, it can restore telomere length - reset the "clock" - thereby increasing the functional lifespan of the cells. Importantly, it does this without altering the cells' biology or causing them to become cancerous.

"Human telomerase, a complex enzyme, is composed of a ribonucleic acid (RNA) component, known as hTR, a protein component, known as hTERT, and other accessory proteins. In 1994, we cloned the gene for hTR, and in 1997, with collaborators, cloned the gene for hTERT.

"The 2009 Nobel Prize for Physiology and Medicine was awarded for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.

"The Nobel laureates were early Geron collaborators, Elizabeth H. Blackburn and Carol W. Greider, along with Jack W. Szostak."

Without further ado, let's start by checking out our telomere length with the help of the folks at Life Length.

Then we'll take it from there.

For other advances in genetic testing, please visit my earlier post on the (now private) genomics pioneer, deCODE Genetics (also featured in Ridley's book).
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Saturday, April 2, 2011

The Heroes of 2011: Japanese Nuclear Workers

2 April 2011

I've been following the New York Times Asia-Pacific page since the Japanese earthquake and tsunami.

I wish to make one point. We knew from the start that the reactors would leak as a consequence of the damage from both an earthquake and a tsunami. Come on, nothing is built to withstand such dual forces of destruction.

And yes, there is serious local leakage of very poisonous and persistent radioactive substances - plutonium, iodine, cesium and more, and they will spread. It's horrible.

But we must remember that (1) nothing nuclear blew up or (fully) melted down and (2) nothing nuclear burned.

Yes, it's disastrous, unimaginable, really. But it could have been far, far worse.

I give full credit to the courageous frontline workers, who knew from the start they would be over-exposed to life-threatening radiation.

They did this for us, and I thank them for their sacrifice on our behalf. When Time Magazine chooses the "person" of the year this year, I hope they remember these workers!
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Tuesday, August 10, 2010

Let's Get the Patents Flowing!

10 August 2010

Bill Fleckenstein posted this thoughtful reflection on the need to foster innovation and creativity on August 9. I am reproducing his words here with his permission:

"I certainly have spent plenty of time over the last decade pointing out the problems and potential problems that the country faces, with none more severe than the protracted nature of the unemployment problem. As the financial crisis was unfolding in late 2008 and early 2009, I actually thought for a while that the incoming administration might try to do something intelligent regarding incentivizing jobs. That was 100% incorrect. The only incentives they have created are ones not to hire more employees, which has only made a bad situation worse. (See the op-ed in today's Wall Street Journal, "Why I'm Not Hiring," to see how the math stacks up against employers.)

"Thus, it is with great pleasure that I can point to something positive. In Friday's New York Times I read about an absolutely brilliant idea described in an article headlined, "Inventing Our Way Out of Joblessness." In it Paul Michel and Henry Nothhaft discussed the potential for breaking the logjam at the patent office and what that might mean. Not being an inventor, I certainly had no idea that the patent office was in quite such a state of disarray. Though I'm not knowledgeable on the subject, one of the authors to me has enough credibility that I think we can take him at his word, that being Paul Michel, who is former chief judge of the United States Court of Appeals for the Federal Circuit, which handles patent appeals.

"Their case is that, apparently, in the venture capital community 75% of startups require some sort of patent to get financing, according to a study they cite. Therefore, it's easy to see the connection between patents and new businesses. The sad, though not surprising, problem is that the patent office can't get enough funding to do its job. According to the authors, since 1992, Congress "has diverted more than $750 million in patent fees to other purposes," which has created a backlog of -- get this -- 1.2 million applications awaiting examination, over half of which haven't even been looked at yet.

"Michel and Nothhaft propose spending $1 billion -- which, when it comes to government these days, is chump change -- to get the patent office streamlined and staffed up so that it can process applications at a reasonable rate. The authors estimate that out of the backlog of 1.2 million applications, based on historical patterns, about 60% of those would result in issued patents, and perhaps as many as 137,000 would go to small businesses, with of course a more efficient patent office processing more patents in ensuing years.

"The net of all that, they feel, would be something on the scale of between 700,000 and 2 million jobs created, depending on what sort of estimates and variables one wants to use. Taking the midrange of their guess, or 1.5 million, that would mean that each job cost the government about $660, which obviously would be a mere pittance relative to the hundreds of billions dollars wasted on government programs that are useless.

"In addition, they suggested that, "Congress should also offer small businesses a tax credit of up to $19,000 for every patent they receive, enabling them to recoup up to half the average $38,000 in patent office and lawyers fees spent to obtain a patent." I would imagine there could be other incentives given on the tax front to help this process along, and I don't see any reason why a patent issued couldn't be fully reimbursed, assuming it ultimately met some sort of sales requirement.

"With so many massive problems staring us in the face, it is damn near criminal incompetence that a problem like this is allowed to fester. I can't see why anyone would be against this, as no one's ox needs to be gored."
_

Tuesday, April 21, 2009

Rescue deCODE Genetics, not GM!

21 April 2009

I have posted previously about the landmark work that deCODE Genetics is carrying out in Iceland.

Unfortunately, this trailblazing company has overextended itself by taking on far-reaching research projects based on the analysis of genetic factors linked to the development of a wide range of human diseases.

deCODE announced on March 31, 2009 that it has run out of funds, is probably no longer a "going concern," and that it will now be divesting its various business units if possible.

Let me make a simple point.

deCODE Genetics is carrying out work that will benefit all of humanity for millennia to come.

General Motors has overextended itself by paying premium salaries to its employees and offering excessive bonuses and other perks to its executives and managers for decades, leading it into an unsustainable business situation.

deCODE Genetics and General Motors are thus in similar circumstances.

However, here is the difference. deCODE Genetics overextended itself doing work that will potentially aid every human being on this planet.

General Motors overextended itself by diverting its revenues to its executives and frontline workers at the expense of operating a profitable business for the benefit of its shareholders.

Rescuing deCODE Genetics would provide lasting benefits to every one of us and all of our descendants.

Rescuing GM will preserve a corporate dinosaur with a legacy of decades of horrible business practices.

I'm serious, let's reorganize the multi-trillion dollar financial rescue programs now being advanced by every Western government and fund the continuing operations of deCODE Genetics - thereby permitting GM to bear the natural consequences of its lengthy and well-documented history of mismanagement.

Somebody else will manufacture the cars and trucks we need if the inefficient automakers are let go.

By way of contrast, if deCODE Genetics goes out of business, important work to promote human health and wellbeing will be delayed for years if not decades to come.

Our priorities are simply wrong.

Here's a desperate suggestion to save deCODE, as no politician in any party is likely to adopt the rational course of action that I am proposing.

Let's set deCODE Genetics up as a registered international charitable foundation. I for one would contribute voluntarily to preserve and promote the work of this wonderful company. deCODE Genetics stands head and shoulders above General Motors by every standard that I can think of. I would rescue this company personally if I only had the means to do so! I wish a few more politicians thought in the same way that I do....

In the interim, I urge those who are interested to consider taking advantage of the innovative "deCODE Me" personal genome scan service now being offered by this company. Believe me, science fiction has now come to life, and the deCODE team are perhaps the leading pioneers in the visionary and critically important field of personal genetic analysis!

(On a side note - I received a personal notice from deCODE today that they have received the personal genetic samples necessary to begin my personal Cardio Scan. I'll be receiving my results very soon!)
_

Tuesday, February 3, 2009

deCODEme - The Era of Genetic Medicine is Here

4 February 2009

This would have been unimaginable at any other time in history. In fact, it only became possible this year.

deCODE Genetics, the visionary Icelandic company headed by Kari Stefansson (a former MIT faculty member and a 2007 Time 100 nominee), is running a February special.

For $100, you can decode your genetic risk
factors for 6 cardiovascular diseases: How and where?

Click
here - you can complete the ordering process in 5 minutes.

How does deCODE do it?


The Icelandic people have kept scrupulous family records for 1000 years. The company uses this data to link the presence or absence of genetically-linked disease with specific gene variants or mutations.


Is CardioScan all there is?

No - in fact you can do more or less a
comprehensive gene scan that will provide you with the following information: There is also a cancer scan here. It will tell you about your genetic risk factors for these conditions: I don't know about you, but I've already sent away for my $100 special CardioScan.

February is American Heart Month, so this scan is
available at this price until February 28.

Don't pass it up. You are now inhabiting the genomic century, and you might as well get used to it!


Enjoy your genome - it's the only one you'll ever have....
_

Monday, June 16, 2008

Mining Replaces Financial Services as Dominant Driver of M&A Activity

16 June 2008

Every now and then I link an article which highlights key points I've been making in this web log.

Today, my link is about the emergence of mining and minerals as the new focus of corporate merger & acquisition activity on Wall Street. This is quite certainly a watershed development in the materials sector.


The link is on the National Post, courtesy of Bloomberg Financial:


Mining replaces financial services as biggest driver of M&A

It is perhaps a refreshing change to see Wall Street refocusing its interest on things that are real (as opposed to the past two decades' increasing emphasis on every imaginable variety of financial engineering).

What is this trend about?

1. Wall Street has exhausted the game-playing that is possible with purely financial investment products due to the cratering of the mortgage-repackaging business.

2. In an era of
out-of-control monetary inflation, real things increase in value while inflating currencies mark the transition to a phase of more rapidly declining values.

3. Formerly isolated nations around the world, from Russia to Tanzania to Brazil and Argentina, and most obviously to the emerging Asian and Middle Eastern superpowers, are joining the international market economy, increasing real global wealth, and creating increased demand for raw materials. (For now, such isolated countries as Venezuela, Bolivia, Zimbabwe and North Korea will be sitting this trend out. It remains to be seen how such countries as Iran and even South Africa will play the new game going forward.)

4. We don't often think of it this way, but energy production from fossil fuels is also a type of mining activity, though in this case the target is geologically-sequestered formerly biological material. While most minerals remain in plentiful supply for now (we just have to build and operate enough mines to recover them), irreplaceable fossil fuels are being rapidly depleted - placing hydrocarbon energy sources at a premium.

5. While the energy industry is currently better-funded than the mineral sector, both will see large new inflows of capital in upcoming decades (the risk being that exhaustion of energy supplies puts a lid on global wealth creation, and ultimately on mineral production as well).

6. Consider the fact that in the still-vibrant mining and mineral-exploration business, most new deposits are not as concentrated as those we exploited in the past. The upshot is that more - increasingly expensive - energy will be required to produce the same quantity of raw materials. That, my friends, is working uphill against an exponentially-increasing gradient!

7. For now, the raw materials trend is positive, but we could at some point see an energy-cost induced global depression which would refocus our activities from continuous extraction of resources to learning how to live a much more resource-constrained, subsistence-based lifestyle.

8. My prediction is that the next trend to follow increased raw materials investment - perhaps still years if not decades away - will be what Buckminster Fuller referred to as ephemeralization: learning how to do more and more with less and less! Combined with nanotechnology, ephemeralization will likely shape the course of the human future for centuries and hopefully millennia to come. Remember - you read it here first!

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Monday, March 31, 2008

The Principles of Tribal Fitness: The Rhythm of the Hunt

31 March 2008, 20 April 2008

I am the archetypal civilized as opposed to tribal person. I am an aficionado of the highest achievements of human culture and civilization, from the great works of art to the accomplishments of music, architecture, drama and literature. While I am hardly the world's most cultured person (you may wish to visit the Juilliard School or the Banff School of Fine Arts to obtain a much greater dose of culture than I can personally convey to you), I am definitely at the civilized as opposed to the tribal end of the human cultural spectrum.

Be that as it may, I am going to spend the balance of this article advocating for a particular aspect of tribal human behaviour.

Why?

Because our survival - as individuals - depends upon mastering the principles of tribal fitness.

If we learn these principles, we stand to live well into the last decades of our lives (no matter how long or short the span that our own genetic program, habitual behaviours and environmental circumstances may actually allow us).

I have referred in an earlier entry to the groundbreaking text on fitness after 50, Younger Next Year. The phrase "rhythm of the hunt" came to me through an entry of Dr. Henry (Harry) Lodge on the Younger Next Year Website.

Dr. Lodge's entry is so well-written, I am tempted to quote it in full here, but that should not be necessary, as you can go directly to the source yourself.

What is Dr. Lodge suggesting?

In essence, humans have lived as tribal beings for over 99% of our two million years of evolution. This simple fact means that very little meaningful biological evolutionary development has occurred during our 7000 years at most of civilized life.

While culturally and psychologically, we may be very civilized beings, biologically, we are tribal beings, and that is simply a fact.

How then did we evolve - biologically - as tribal peoples?

In one term - as hunter-gatherers.

Again, no more than 1% of human evolution has been characterized by the three developmental stages subsequent to the hunter-gatherer lifestyle (horticultural/pastoral; chiefdom; civil society).

How do hunter-gatherers live?

Again, the brief answer is "from the gifts of the land." From a civilized perspective, that may seem a difficult lifestyle, but it was obviously good enough to tide our ancestors through 2 million years of evolutionary history.

For hunter/gatherers, sometimes the land gave, and sometimes it did not.

Going beyond Dr. Lodge, I would speculatively characterize the tribal (hunter/gatherer) lifestyle as involving three phases - linked to three types of activity.

Phase I is gathering the fruits of the land. The activity associated with gathering was probably many hours of walking, bending, stooping, digging, collecting, and intermittently resting, per day. While gathering implies a vegetarian component to our diet, this was not strictly a vegetarian activity, as many animal sources of nutrition are also susceptible to gathering, including the collection of shellfish, the gathering of eggs, and probably catching fish in many cases as well.

Phase I is characterized by a gentle sustained pace of exercise mostly equivalent to walking or jogging as an exercise form.

Phase II is hunting, and to the best of our knowledge, based on the study of contemporary hunter/gatherer societies, this was characteristically a group activity, and was accompanied by a number of active rituals, as well as by hunting forays to bring home high protein/high fat game for the tribal group.

Hunting involves not only vigorous running and effortful use of weapons and carrying of the kill, but also many complex and integrated bodily movements, such as twisting, striking, lifting, cutting, turning, altering direction and pace, etc.

Phase III - not mentioned by Dr. Lodge, but also obviously relevant to the tribal lifestyle, is fasting. In pastoral societies, such as that of the traditional Hunza, fasting was an essential element of the annual calendar, extending up to 6 weeks in late winter and early spring.

Periods of fasting are a time for conservation of energy. Notably, the scarcity of food has defined much about human biological development. Consider, for example, that our bodies' insistence upon the storage of fat is clearly an adaptation to the recurring shortage of food during our human and pre-human developmental history. When we diet, our bodies move into food scarcity mode, and increase the rate at which they store fat, frustrating the intentions of many would-be dieters.

Consider also that depressed mood is a survival mechanism in times of scarcity, as depressed individuals conserved energy, while active individuals risked wasting what little energy might have been stored in fat, with the result that they might not survive until the next season of plenitude.

By way of contrast, and here I am returning to the main point of Dr. Lodge's article, hunting is an optimistic activity. The hunter, through the expenditure of great effort, increases his chances of bringing home many meals, and thereby enhancing his chances of survival, as well as the likelihood of survival of his tribal group.

That is, biologically, the rhythm of the hunt offers some survival advantages over the rhythm of foraging.

To begin with, the slow, steady pace of the walking gatherer is a biological strategy for burning fat, but not carbohydrates. I suspect, though I'm reading between the lines in the evidence, that psychological depression (for the reasons I offered earlier) is also linked to the foraging versus the hunting way of life.

By way of contrast, the vigorous pace of the hunter entails the burning of the combined fuels of fat and carbohydrate, as well as to much more active use of the body as a whole - and this also appears to be linked to counterbalancing psychological processes.

Dr. Lodge states:

"Exercising hard enough to push yourself to the next level calls for a new fuel. You need more power than you get from fat alone, so your muscles start to burn glucose. This shift into high gear changes your metabolism, because harder exercise is the automatic signal to your body that you've started to hunt. Picture an animal when prey is in sight. His adrenaline surges, he becomes engaged and alert, his step has more bounce, he processes visual information more quickly, his reflexes sharpen, his pupils dilate. This is what happens when you turn on a whole serious of complex control mechanisms by exercising harder. When you reach this level, —starting to burn glucose—, your arms swing freely, you breathe more deeply, and your legs start to really work. You keep burning that low level of fat in the background, but all the extra fuel from this point on up is glucose.

"Your heart rate is the only way to know for sure which metabolism is at work and which signals you're sending. Your heart delivers more and more blood to your muscles the faster it pumps, and your muscles can extract more and more fat from that blood until you reach about 65 percent of your peak heart rate. That's the limit of your first gear, and only a heart monitor can help you determine which number that is for you. As soon as you push your body a little harder, you start burning glucose in addition to fat, and you need more oxygen to do this. That means bringing more blood to the muscles so your heart rate goes up. Any heart rate above 65 percent means you're burning glucose and that you've moved into a different metabolism. You've shifted into second gear and your body starts drawing on the glucose stored in your muscles, feeding it into your mitochondria to produce extra energy.

"Hard aerobics, working up a good sweat, is our favourite exercise rhythm because hunting brings out our youngest and best biology: strong, fast, energetic and optimistic all day long. But light aerobics builds the foundation for health better than anything else. That's why you should do light aerobic exercise a couple of days a week to build your base, and then go out and play on the hard-aerobic fields the other days."

I have quoted Dr. Lodge at length here, because there is little that I wanted to omit, and little that could be paraphrased more concisely.

The rhythm of the hunt, due to the efficient mitochondrial (aerobic) burning of carbohydrate fuel, engages a series of rejuvenating biological mechanisms that are not triggered by more moderate exercise.

In my earlier essay on the ideas of Younger Next Year, I made reference to the impacts of the cytokines 6 and 10 on human health and fitness. New research since that time has revealed that both cytokine 6 (more commonly referred to as IL6) and cytokine 10 (IL10) are anti-inflammatory cell-surface signalling proteins, and that the culprit involved in the cellular breakdown associated with arthritis, diabetes and cardiovascular disease is actually another very well-characterized cytokine known as TNF (I am simplifying perhaps too much in this section, for the sake of hoped-for clarity).

However, the fundamental idea of younger next year, and the first principle of tribal fitness, still stands.

When we do not exercise vigorously on at least an alternating daily basis, our bodies enter fasting mode.

Paradoxically, even when we are inactive, but flooding our bodies with calories, biologically, our bodies remain in fasting mode - because it is vigorous physical activity that signals our bodies that we are engaged in the gathering of food - not the inflow of calories!

The body of the well-fed inactive person believes it is starving. Not only does it begin to store fat at overtime rates, it also breaks down tissue to generate energy to burn - and this is the mechanism which triggers the onset of arthritis, diabetes and cardiovascular disease, as well as probably many other diseases, possibly including some types of cancer as well.

What about the biology of the gatherer?

It is much healthier than the biology of the inactive person, but still problematic, at least in our contemporary context, where our closest approximation to gathering is walking. That is, the original spectrum of "lifestyle" components of traditional gathering behaviour is typically eliminated in our contemporary forms of "moderate" exercise.

How so?

Quite simply, our bodies do not require the peak of fitness to walk about, staying active, but at no more than an easy to moderate pace. When we walk and take in calories, our bodies know that food is available - but easily so. Thus, muscle tissue gradually dies back, and the range of our bodies' capacity for exertion becomes restricted. This is not a serious problem for younger people, but potentially a very serious problem for persons over 50, who are already facing age-related declines in physical capacity.

That is, even regular but only mellow physical exercise permits us to come off our peak, and to function in a gradually narrower and narrower range.

Thus, of the three "phases" of tribal fitness, only one of the three enables us to live beyond age 50 with as full as possible a range of capacities - and that is phase II - the rhythm of the hunt.

As defined by Dr. Lodge, this means engaging our heart rate at 65% or more of maximum capacity, and engaging in strenuous (though not necessarily continuous) physical exertion (characterized in the text as "resistance training").

On the Younger Next Year website, Dr. Lodge and his partner Chris Crowley, are beginning to define more broadly what is really entailed by the rhythm of the hunt.

On the title page at this time is a reference to the new book, "Balance," by Scott McCredie. Mr. Crowley refers to Mr McCredie's conjecture that it may have been our human sense of balance - not our supposedly superior intelligence - that distinguished us from the Neanderthal.

Let me go beyond Crowley and Lodge here to add a few questions or conjectures of my own.

As I really understand the physical demands of the hunt in tribal societies (and let me hasten to add that I am a vegetarian, but my genetic code doesn't know it), there is much more demanded of our minds and bodies than our contemporary analogues of aerobic fitness, speedwork and weight training.

That is, our "linearly" structured contemporary exercise programs constitute no more than partial approximations of the actual rhythm of the hunt that we must replicate if we are interested in arresting the progress of the degenerative processes (and diseases) that are inherent to the aging process, as well as in maximizing our physical options through maintaining peak levels of endurance, strength, flexibility and agility.

I am beginning to think that combined aerobics and strength training, while beneficial - are simply not enough. I am not meaning to set an impossible challenge in terms of the time demands of fitness activities, but rather to be interested in thinking about how to combine activities that promote endurance, strength, balance, flexibility, agility and tolerance for variation in levels of effort.

That is - it is not "one or the other," but how to combine as many functions into a single activity as suits our personal interests, needs, constraints and lifestyle.

As a thought experiment, let me set out a few basic challenges, some of which I can presently pass, but some of which I cannot - and probably soon must be able to do!

Targeting particularly my readers over 50, can you.....

1. Complete a half marathon in any time at all?
2. Lift (pull up) your own body's weight on a horizontal bar?
3. Push up your own body's weight with your arms?
4. Easily exit a chair by exerting your abdominal muscles rather than by relying on the support and strength in your arms?
5. Comfortably assume and maintain a full squatting position (as one might witness in an Asian market)?
6. Both sit up and stand up from a lying-down (supine) position without using your arms to push or pull?
7. Maintain your balance while riding a bicycle or a horse over long distances?
8. Take off, put on, tie and untie your shoes from a standing position without support?
9. Run, turn and spin from position to position without losing your balance?
10. Engage in at least three demanding lifestyle fitness activities (for example, team sports, individual competitive sports, distance running, rock climbing, cycle touring, skiing, roller blading, distance swimming, active dancing, etc.)?
11. Run and keep your pace in deep snow or sand?
12. Balance on one leg (or better still - two arms)?

If you are 50, will you be able to do these activities when you are 70? Or if you are 60, to do them at 80, etc.?

What kind of fitness routine do you need to accomplish your own strategy for being "younger next year?"

There is much more I want to say, ask, and speculate about, but I will reserve these additional topics for a future article!

20 April 2008: It is important to clarify a point that is raised by my wife Susan in her recent blog entry, "Long Walks Are Good for Your Heart x2." She is exactly right that the transition from idleness to maximum exertion is a non-natural and high-risk behavioural pattern.

It would be more accurate to conclude not that the rhythm of the hunt is superior to the rhythm of foraging, but rather that it is a necessary and non-expendable complement to the pace of foraging. To rest and then to hunt, never engaging in foraging, seems an unlikely and unnatural life and exercise rhythm.

The rhythm of the hunt gains its validation against the backdrop of the rhythm of foraging. Both are necessary. Seeking to capture the pace of the hunter in our exercise program, without also mastering the pace of the gatherer, is almost certainly contraindicated by the innate biological program of our hunter-gatherer bodies!

Further, we would be wise to devote more time to mastering the rhythm of the gatherer prior to aspiring to the replication of the rhythm of the hunt. That is, let us first attain the rhythms of gathering and foraging before we seek to master the challenges of the far more demanding - and risky - rhythms of the hunt.

It is the gatherer who is ready to engage in the mysteries and rituals of the hunt, not the sedentary individual whose body is unaccustomed to regular and habitual movement and sustained aerobic exertion.

In the world of evolutionary (physical) fitness, we must certainly learn to walk before we can learn to run.